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Anaplasma phagocytophilum

Paul G. Auwaerter, M.D.
Anaplasma phagocytophilum is a topic covered in the Johns Hopkins ABX Guide.

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  • Cause of tick-borne infection in humans.
  • Human granulocytic anaplasmosis (HGA), formerly known as human granulocytic ehrlichiosis (HGE).
    • Organism is now known as Anaplasma phagocytophilum transmitted by Ixodes scapularis (black-legged deer tick) on Eastern Seaboard, New England, Mid-Atlantic, and Upper Midwest, and on the West Coast by the western black-legged tick (Ixodes pacificus)—the same vectors as for Lyme disease (Borrelia burgdorferi).
    • Obligate, intracellular pathogen that tends to multiply in granulocytes within vacuoles that may form morulae.
      • See Ehrlichia spp. module for disease (human mononcytic ehrlichiosis [HME] and others) caused by these similar tick-borne pathogens.

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Last updated: September 3, 2016


Auwaerter, Paul G. "Anaplasma Phagocytophilum." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum.
Auwaerter PG. Anaplasma phagocytophilum. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum. Accessed March 24, 2019.
Auwaerter, P. G. (2016). Anaplasma phagocytophilum. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum
Auwaerter PG. Anaplasma Phagocytophilum [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 March 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Anaplasma phagocytophilum ID - 540609 A1 - Auwaerter,Paul,M.D. Y1 - 2016/09/03/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540609/all/Anaplasma_phagocytophilum PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -