Anaplasma phagocytophilum

Paul G. Auwaerter, M.D.
Anaplasma phagocytophilum is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Cause of tick-borne infection in humans.
  • Human granulocytic anaplasmosis (HGA), formerly known as human granulocytic ehrlichiosis (HGE).
    • The organism is currently known as Anaplasma phagocytophilum transmitted by Ixodes scapularis (black-legged deer tick) on Eastern Seaboard, New England, Mid-Atlantic, and Upper Midwest, and on the West Coast by the western black-legged tick (Ixodes pacificus)—the same vectors as for Lyme disease (Borrelia burgdorferi).
    • An obligate, intracellular pathogen that tends to multiply in granulocytes within vacuoles that may form morulae.
      • See Ehrlichia spp. module for disease (human monocytic ehrlichiosis [HME] and others) caused by these similar tick-borne pathogens.

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MICROBIOLOGY

  • Cause of tick-borne infection in humans.
  • Human granulocytic anaplasmosis (HGA), formerly known as human granulocytic ehrlichiosis (HGE).
    • The organism is currently known as Anaplasma phagocytophilum transmitted by Ixodes scapularis (black-legged deer tick) on Eastern Seaboard, New England, Mid-Atlantic, and Upper Midwest, and on the West Coast by the western black-legged tick (Ixodes pacificus)—the same vectors as for Lyme disease (Borrelia burgdorferi).
    • An obligate, intracellular pathogen that tends to multiply in granulocytes within vacuoles that may form morulae.
      • See Ehrlichia spp. module for disease (human monocytic ehrlichiosis [HME] and others) caused by these similar tick-borne pathogens.

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