Johns Hopkins ABX Guide
Piperacillin + Tazobactam
INDICATIONS
FDA
FDA
- Gynecologic infections (pelvic inflammatory disease, postpartum endometritis)
- Intra-abdominal infections (peritonitis, appendicitis, cholecystitis)
- Skin and skin structure infections (including diabetic foot infections)
- Community-acquired pneumonia
- Nosocomial pneumonia
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Endocarditis caused by Enterobacteriaceae and Pseudomonasspp. (usually in combination with aminoglycosides)
- Aspiration pneumonia, lung abscess, empyema
- Ventilator-associated pneumonia
- Neutropenic fever
- Bacteremia caused by Pseudomonas spp. or polymicrobial
- Empiric therapy for a variety of infections where a broad-spectrum agent is needed, including sepsis (except for meningitis)
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Last updated: January 15, 2026
Citation
Avdic, Edina, and Caitlin Soto. "Piperacillin + Tazobactam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540434/0.1/Piperacillin_+_Tazobactam.
Avdic E, Soto C. Piperacillin + Tazobactam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540434/0.1/Piperacillin_+_Tazobactam. Accessed January 16, 2026.
Avdic, E., & Soto, C. (2026). Piperacillin + Tazobactam. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540434/0.1/Piperacillin_+_Tazobactam
Avdic E, Soto C. Piperacillin + Tazobactam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 January 16]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540434/0.1/Piperacillin_+_Tazobactam.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Piperacillin + Tazobactam
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A1 - Avdic,Edina,Pharm.D.
AU - Soto,Caitlin,PharmD, BCIDP,
Y1 - 2026/01/15/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540434/0.1/Piperacillin_+_Tazobactam
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
