Penicillin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS
Penicillin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Endocarditis
  • Skin and soft tissue infection (erysipelas, erysipeloid)
  • Rat-bite fever
  • Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
  • Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
  • Actinomycosis
  • Empyema
  • Pasteurella infections
  • Pneumonia
  • Upper respiratory tract infection: Group A strep pharyngitis, otitis media
  • Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
  • Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease

NON-FDA APPROVED USES

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INDICATIONS

FDA

  • Endocarditis
  • Skin and soft tissue infection (erysipelas, erysipeloid)
  • Rat-bite fever
  • Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
  • Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
  • Actinomycosis
  • Empyema
  • Pasteurella infections
  • Pneumonia
  • Upper respiratory tract infection: Group A strep pharyngitis, otitis media
  • Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
  • Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease

NON-FDA APPROVED USES

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Last updated: December 8, 2019