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Penicillin is a topic covered in the Johns Hopkins ABX Guide.

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  • Endocarditis
  • Skin and soft tissue infection (erysipelas, erysipeloid)
  • Rat-bite fever
  • Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
  • Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as first line agent due to beta-lactamase production (see "biodefense-anthrax")]
  • Actinomycosis
  • Empyema
  • Pasteurella infections
  • Pneumonia
  • Upper respiratory tract infection: Group A strep pharyngitis, otitis media
  • Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
  • Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease


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Last updated: February 4, 2014


Pham, Paul A, and John G Bartlett. "Penicillin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2014. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540424/all/Penicillin.
Pham PA, Bartlett JG. Penicillin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2014. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540424/all/Penicillin. Accessed April 23, 2019.
Pham, P. A., & Bartlett, J. G. (2014). Penicillin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540424/all/Penicillin
Pham PA, Bartlett JG. Penicillin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2014. [cited 2019 April 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540424/all/Penicillin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Penicillin ID - 540424 A1 - Pham,Paul,Pharm.D. AU - Bartlett,John,M.D. Y1 - 2014/02/04/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540424/all/Penicillin PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -