Penicillin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS
Penicillin is a topic covered in the Johns Hopkins ABX Guide.

To view the entire topic, please log in or purchase a subscription.

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

Pediatrics Central

Abdominal MassAbdominal Mass

metoprololmetoprolol

Hepatic AbscessHepatic Abscess

Inguinal HerniaInguinal Hernia

-- The first section of this topic is shown below --

INDICATIONS

FDA

  • Endocarditis
  • Skin and soft tissue infection (erysipelas, erysipeloid)
  • Rat-bite fever
  • Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
  • Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
  • Actinomycosis
  • Empyema
  • Pasteurella infections
  • Pneumonia
  • Upper respiratory tract infection: Group A strep pharyngitis, otitis media
  • Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
  • Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease

NON-FDA APPROVED USES

  • Brain abscess
  • Lung abscess
  • Endocarditis -β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
  • Necrotizing fasciitis (S. pyogenes)
  • Gas gangrene
  • Lyme arthritis
  • Neisseria meningitidis 
  • All stages of syphilis (Treponema pallidum)
  • Osteomyelitis and prosthetic joint infections- β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
  • Cutibacterium (Propionibacterium) acnes infections
  • Clostridium infections
  • Meningitis- susceptible S. pneumoniae, S. agalactiae, Listeria

-- To view the remaining sections of this topic, please log in or purchase a subscription --

INDICATIONS

FDA

  • Endocarditis
  • Skin and soft tissue infection (erysipelas, erysipeloid)
  • Rat-bite fever
  • Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
  • Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
  • Actinomycosis
  • Empyema
  • Pasteurella infections
  • Pneumonia
  • Upper respiratory tract infection: Group A strep pharyngitis, otitis media
  • Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
  • Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease

NON-FDA APPROVED USES

  • Brain abscess
  • Lung abscess
  • Endocarditis -β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
  • Necrotizing fasciitis (S. pyogenes)
  • Gas gangrene
  • Lyme arthritis
  • Neisseria meningitidis 
  • All stages of syphilis (Treponema pallidum)
  • Osteomyelitis and prosthetic joint infections- β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
  • Cutibacterium (Propionibacterium) acnes infections
  • Clostridium infections
  • Meningitis- susceptible S. pneumoniae, S. agalactiae, Listeria

There's more to see -- the rest of this entry is available only to subscribers.