Penicillin
Penicillin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Endocarditis
- Skin and soft tissue infection (erysipelas, erysipeloid)
- Rat-bite fever
- Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
- Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
- Actinomycosis
- Empyema
- Pasteurella infections
- Pneumonia
- Upper respiratory tract infection: Group A strep pharyngitis, otitis media
- Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
- Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Brain abscess
- Lung abscess
- Endocarditis -β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
- Necrotizing fasciitis (S. pyogenes)
- Gas gangrene
- Lyme arthritis
- Neisseria meningitidis
- All stages of syphilis (Treponema pallidum)
- Osteomyelitis and prosthetic joint infections- β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
- Cutibacterium (Propionibacterium) acnes infections
- Clostridium infections
- Meningitis- susceptible S. pneumoniae, S. agalactiae, Listeria
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INDICATIONS
FDA
FDA
- Endocarditis
- Skin and soft tissue infection (erysipelas, erysipeloid)
- Rat-bite fever
- Vincent’s infection fusospirochetosis (Vincent’s gingivitis and pharyngitis)
- Anthrax due to Bacillus anthracis, including inhalation anthrax (post-exposure): PCN procaine [note: CDC does not recommend as the first-line agent due to beta-lactamase production (see "biodefense-anthrax")]
- Actinomycosis
- Empyema
- Pasteurella infections
- Pneumonia
- Upper respiratory tract infection: Group A strep pharyngitis, otitis media
- Venereal infections (penicillin G benzathine suspension): syphilis and neurosyphilis
- Rheumatic fever prophylaxis, chorea prophylaxis, glomerulonephritis prophylaxis, rheumatic heart disease
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Brain abscess
- Lung abscess
- Endocarditis -β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
- Necrotizing fasciitis (S. pyogenes)
- Gas gangrene
- Lyme arthritis
- Neisseria meningitidis
- All stages of syphilis (Treponema pallidum)
- Osteomyelitis and prosthetic joint infections- β-hemolytic streptococci, S. pneumoniae, Viridans group streptococci, enterococcus.
- Cutibacterium (Propionibacterium) acnes infections
- Clostridium infections
- Meningitis- susceptible S. pneumoniae, S. agalactiae, Listeria
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