Morganella is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Facultative anaerobic Gram-negative rod.
    • Non-lactose fermenter in the same family as Proteus.
    • Environmentally ubiquitous, part of normal colonic flora.
    • "Urea splitter," but stones are seen less frequently than Proteus due to less effective urease enzyme.
  • Morganella only has a single member in its genus M. morganii, and two subspecies: M. morganii and M. sibonii, which differ only in trehalose fermentation.
  • Antimicrobial susceptibility:
    • Naturally resistant to penicillin, ampicillin, first-, second-generation cephalosporins, fosfomycin, macrolides.
    • Beta-lactamase is inducible, AmpC type but less commonly seen than with Enterobacter, Serratia.
    • Production of extended-spectrum beta-lactamases, including carbapenemases Amber class B -such as New Delhi metallo-β-lactamase 1 (NDM-1)- and Amber class D -such as OXA-181- as well as fluoroquinolone resistance have been reported.
    • Tigecycline is not reliably effective due to ArcAB efflux pump, although may show synergy in vitro with other antimicrobials[8].

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Last updated: September 27, 2019