is a topic covered in the Johns Hopkins ABX Guide
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- Facultative anaerobic Gram-negative rod.
- Non-lactose fermenter in the same family as Proteus.
- Environmentally ubiquitous, part of normal colonic flora.
- "Urea splitter," but stones are seen less frequently than Proteus due to less effective urease enzyme.
- Morganella only has a single member in its genus M. morganii, and two subspecies: M. morganii and M. sibonii, which differ only in trehalose fermentation.
- Antimicrobial susceptibility:
- Naturally resistant to penicillin, ampicillin, first-, second-generation cephalosporins, fosfomycin, macrolides.
- Beta-lactamase is inducible, AmpC type but less commonly seen than with Enterobacter, Serratia.
- Production of extended-spectrum beta-lactamases, including carbapenemases Amber class B -such as New Delhi metallo-β-lactamase 1 (NDM-1)- and Amber class D -such as OXA-181- as well as fluoroquinolone resistance have been reported.
- Tigecycline is not reliably effective due to ArcAB efflux pump, although may show synergy in vitro with other antimicrobials.
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