Levofloxacin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.

Levofloxacin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

Acute bacterial exacerbations of chronic bronchitis (ABECB)
Acute bacterial sinusitis
Uncomplicated urinary tract infections
Note: use of levofloxacin for these indications should be avoided due recent FDA warning (Boxed warning) regarding serious side effects and potentially permanent (tendonitis and tendon rapture, peripheral neuropathy and CNS side effects). FDA safety warning regarding Fluoroquinolone use
Pneumonia: community-acquired pneumonia and nosocomial pneumonia
Inhalational anthrax (post-exposure)
Uncomplicated and complicated skin and soft tissue infections (not MRSA)
Complicated urinary tract infections
Acute pyelonephritis
Bacterial conjunctivitis (Quixin 0.5% opthalmic drops)
- Treatment of corneal ulcer (1.5% ophthalmic solution)
Chronic bacterial prostatitis

NON-FDA

Treatment of M. tuberculosis including MDR and XDR-TB (in combination with other agents)

Treatment of MAI and other non-TB mycobacterial infections (in combination with other agents)
Alternative therapy for treatment of S. pneumoniae and H. influenzae meningitis in patients who have severe penicillin allergies.
Bone and joint infections
Intra-abdominal infections in combination with metronidazole
H. pylori in combination with other agents
Prophylaxis in neutropenic patients

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Last updated: July 2, 2017

Citation

Avdic, Edina, and Paul A Pham. "Levofloxacin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin.

Avdic E, Pham PA. Levofloxacin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin. Accessed January 22, 2019.

Avdic, E., & Pham, P. A. (2017). Levofloxacin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin

Avdic E, Pham PA. Levofloxacin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 January 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin

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TY - ELEC T1 - Levofloxacin ID - 540312 A1 - Avdic,Edina,Pharm.D. AU - Pham,Paul,Pharm.D. Y1 - 2017/07/02/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -