Johns Hopkins ABX Guide
Levofloxacin
Levofloxacin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Acute bacterial exacerbations of chronic bronchitis (ABECB)
- Acute bacterial sinusitis
- Uncomplicated urinary tract infections
- Note: use of levofloxacin for these indications should be avoided due recent FDA warning (Boxed warning) regarding serious side effects and potentially permanent (tendonitis and tendon rapture, peripheral neuropathy and CNS side effects). FDA safety warning regarding Fluoroquinolone use
- Pneumonia: community-acquired pneumonia and nosocomial pneumonia
- Inhalational anthrax (post-exposure)
- Uncomplicated and complicated skin and soft tissue infections (not MRSA)
- Complicated urinary tract infections
- Acute pyelonephritis
- Bacterial conjunctivitis (Quixin 0.5% opthalmic drops)
- Treatment of corneal ulcer (1.5% ophthalmic solution)
- Chronic bacterial prostatitis
NON-FDA
NON-FDA
- Treatment of M. tuberculosis including MDR and XDR-TB (in combination with other agents)
- Treatment of MAI and other non-TB mycobacterial infections (in combination with other agents)
- Alternative therapy for treatment of S. pneumoniae and H. influenzae meningitis in patients who have severe penicillin allergies.
- Bone and joint infections
- Intra-abdominal infections in combination with metronidazole
- H. pylori in combination with other agents
- Prophylaxis in neutropenic patients
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INDICATIONS
FDA
FDA
- Acute bacterial exacerbations of chronic bronchitis (ABECB)
- Acute bacterial sinusitis
- Uncomplicated urinary tract infections
- Note: use of levofloxacin for these indications should be avoided due recent FDA warning (Boxed warning) regarding serious side effects and potentially permanent (tendonitis and tendon rapture, peripheral neuropathy and CNS side effects). FDA safety warning regarding Fluoroquinolone use
- Pneumonia: community-acquired pneumonia and nosocomial pneumonia
- Inhalational anthrax (post-exposure)
- Uncomplicated and complicated skin and soft tissue infections (not MRSA)
- Complicated urinary tract infections
- Acute pyelonephritis
- Bacterial conjunctivitis (Quixin 0.5% opthalmic drops)
- Treatment of corneal ulcer (1.5% ophthalmic solution)
- Chronic bacterial prostatitis
NON-FDA
NON-FDA
- Treatment of M. tuberculosis including MDR and XDR-TB (in combination with other agents)
- Treatment of MAI and other non-TB mycobacterial infections (in combination with other agents)
- Alternative therapy for treatment of S. pneumoniae and H. influenzae meningitis in patients who have severe penicillin allergies.
- Bone and joint infections
- Intra-abdominal infections in combination with metronidazole
- H. pylori in combination with other agents
- Prophylaxis in neutropenic patients
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Last updated: July 2, 2017
Citation
Avdic, Edina, and Paul A Pham. "Levofloxacin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin.
Avdic E, Pham PA. Levofloxacin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin. Accessed January 26, 2020.
Avdic, E., & Pham, P. A. (2017). Levofloxacin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin
Avdic E, Pham PA. Levofloxacin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2020 January 26]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540312/all/Levofloxacin.
* Article titles in AMA citation format should be in sentence-case
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PB - The Johns Hopkins University
DB - Pediatrics Central
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