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Intravenous immune globulin is a topic covered in the Johns Hopkins ABX Guide.

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  • Bone marrow transplant (to prevent graft vs host disease)
  • Primary immunoglobulin deficiency
  • Idiopathic thrombocytopenia (ITP)
  • Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended); Kawasaki disease.
  • VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)


  • Anemia due to parvovirus B19 infection.
  • Non-FDA approved indications with established efficacy: Guillain-Barre syndrome; steroid resistant dermatomyositis; multifocal motor neuropathy.
  • Non-FDA approved indications that is still controversial: patients with Strep TSS treated with IVIG had a trend toward a lower mortality rate.
  • Severe C. difficile-associated colitis (based on case reports) .

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Last updated: February 2, 2011


Pham, Paul A, and John G Bartlett. "Intravenous Immune Globulin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2011. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540292/all/Intravenous_immune_globulin.
Pham PA, Bartlett JG. Intravenous immune globulin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2011. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540292/all/Intravenous_immune_globulin. Accessed April 22, 2019.
Pham, P. A., & Bartlett, J. G. (2011). Intravenous immune globulin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540292/all/Intravenous_immune_globulin
Pham PA, Bartlett JG. Intravenous Immune Globulin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2011. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540292/all/Intravenous_immune_globulin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Intravenous immune globulin ID - 540292 A1 - Pham,Paul,Pharm.D. AU - Bartlett,John,M.D. Y1 - 2011/02/02/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540292/all/Intravenous_immune_globulin PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -