Intravenous immune globulin
Intravenous immune globulin is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Bone marrow transplant (to prevent graft vs host disease)
- Primary immunoglobulin deficiencies (hypogammaglobulinemia)
- Idiopathic thrombocytopenic purpura (ITP)
- Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended)
- Kawasaki disease
- VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Autoimmune hemolytic anemias
- Pure red cell aplasia
- Guillain-Barre syndrome
- Steroid resistant dermatomyositis
- Polymyositis
- Multifocal motor neuropathy
- Multiple myeloma
- Immune-mediated neutropenia
- Post-transfusion purpura
- Neonatal alloimmune thrombocytopenia
- Solid-organ transplant
- Myasthenia gravis
- Multiple sclerosis
- Systemic lupus diseases
- Systemic vascular syndrome and vasculitis
- Refractory seizures
- Chronic inflammatory demyelinating polyneuropathy
- Stiff person syndrome
- Paraneoplastic syndrome
- Thrombocytopenia refractory to platelet transfusion
- Immune deficiencies and immune regulatory disorders
Infectious Diseases Use
- Measles post-exposure prophylaxis
- Adjective therapy for RSV in the severely immunocompromised host (e.g. BMT)
- Severe C. difficile-associated colitis
- Anemia due to parvovirus B19 infection
- CMV infections
- BK virus nephropathy[1]
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INDICATIONS
FDA
FDA
- Bone marrow transplant (to prevent graft vs host disease)
- Primary immunoglobulin deficiencies (hypogammaglobulinemia)
- Idiopathic thrombocytopenic purpura (ITP)
- Prevention of bacterial infections in HIV-infected children who are not receiving prophylaxis (FDA approved but generally not recommended)
- Kawasaki disease
- VZV post-exposure prophylaxis (if Varicella-Zoster immune globulin is not available)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Autoimmune hemolytic anemias
- Pure red cell aplasia
- Guillain-Barre syndrome
- Steroid resistant dermatomyositis
- Polymyositis
- Multifocal motor neuropathy
- Multiple myeloma
- Immune-mediated neutropenia
- Post-transfusion purpura
- Neonatal alloimmune thrombocytopenia
- Solid-organ transplant
- Myasthenia gravis
- Multiple sclerosis
- Systemic lupus diseases
- Systemic vascular syndrome and vasculitis
- Refractory seizures
- Chronic inflammatory demyelinating polyneuropathy
- Stiff person syndrome
- Paraneoplastic syndrome
- Thrombocytopenia refractory to platelet transfusion
- Immune deficiencies and immune regulatory disorders
Infectious Diseases Use
- Measles post-exposure prophylaxis
- Adjective therapy for RSV in the severely immunocompromised host (e.g. BMT)
- Severe C. difficile-associated colitis
- Anemia due to parvovirus B19 infection
- CMV infections
- BK virus nephropathy[1]
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