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HHV 6/HHV 7

Robin Avery, M.D., Paul Auwaerter, M.D.
HHV 6/HHV 7 is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • HHV-6 and HHV-7 are members of the β-herpesvirus family.
  • Closely related to each other and CMV.
  • HHV-6 infects mature T-lymphocytes (CD4>CD8), monocytes, macrophages, megakaryocytes and glial cells. Remains dormant in PBMCs.
    • HHV-6 has 2 subtypes:
      • 6A: only accounts for 1-3% disease, may be more neurotropic.
      • 6B: appears responsible for most disease in solid organ transplant (SOT)/hematopoietic cell transplant (HCT)/immunocompromised populations.
      • Approximately 1% of the population has chromosomally integrated HHV-6 (ciHHV-6), sometimes leading to unnecessary treatment for HHV-6
  • HHV-7 infects T-lymphocytes (CD4>>CD8).

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Last updated: January 29, 2017

Citation

Avery, Robin, and Paul Auwaerter. "HHV 6/HHV 7." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7.
Avery R, Auwaerter P. HHV 6/HHV 7. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7. Accessed April 21, 2019.
Avery, R., & Auwaerter, P. (2017). HHV 6/HHV 7. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7
Avery R, Auwaerter P. HHV 6/HHV 7 [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 April 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - HHV 6/HHV 7 ID - 540270 A1 - Avery,Robin,M.D. AU - Auwaerter,Paul,M.D. Y1 - 2017/01/29/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7 PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -