Johns Hopkins ABX Guide
HHV 6/HHV 7
MICROBIOLOGY
- HHV-6 [Fig 1] and HHV-7 are members of the β-herpesvirus family.
- Closely related to each other and CMV.
- HHV-6 infects mature T-lymphocytes (CD4>CD8), monocytes, macrophages, megakaryocytes and glial cells. Remains dormant in PBMCs.
- HHV-6 has 2 subtypes:
- 6A: only accounts for 1-3% of disease, maybe more neurotropic.
- 6B: appears responsible for most disease in solid organ transplant (SOT)/hematopoietic cell transplant (HCT)/immunocompromised populations.
- Approximately 1% of the population has chromosomally integrated HHV-6 (ciHHV-6), sometimes leading to unnecessary treatment for HHV-6
- HHV-6 has 2 subtypes:
- HHV-7 infects T-lymphocytes (CD4>>CD8).
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Last updated: July 4, 2022
Citation
Avery, Robin, and Paul Auwaerter. "HHV 6/HHV 7." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7.
Avery R, Auwaerter P. HHV 6/HHV 7. Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7. Accessed November 21, 2024.
Avery, R., & Auwaerter, P. (2022). HHV 6/HHV 7. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7
Avery R, Auwaerter P. HHV 6/HHV 7 [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2022. [cited 2024 November 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7.
* Article titles in AMA citation format should be in sentence-case
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A1 - Avery,Robin,M.D.
AU - Auwaerter,Paul,M.D.
Y1 - 2022/07/04/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540270/all/HHV_6_HHV_7
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
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