HHV 6/HHV 7
HHV 6/HHV 7
is a topic covered in the Johns Hopkins ABX Guide
To view the entire topic, please sign in or purchase a subscription.
Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:
-- The first section of this topic is shown below --
- HHV-6 and HHV-7 are members of the β-herpesvirus family.
- Closely related to each other and CMV.
- HHV-6 infects mature T-lymphocytes (CD4>CD8), monocytes, macrophages, megakaryocytes and glial cells. Remains dormant in PBMCs.
- HHV-6 has 2 subtypes:
- 6A: only accounts for 1-3% disease, may be more neurotropic.
- 6B: appears responsible for most disease in solid organ transplant (SOT)/hematopoietic cell transplant (HCT)/immunocompromised populations.
- Approximately 1% of the population has chromosomally integrated HHV-6 (ciHHV-6), sometimes leading to unnecessary treatment for HHV-6
- HHV-7 infects T-lymphocytes (CD4>>CD8).
-- To view the remaining sections of this topic, please sign in or purchase a subscription --