Genital Ulcer Adenopathy Syndromes
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PATHOGENS
Infectious Causes
- Common Sexually Transmitted Infections:
- Herpes simplex virus
- Treponema pallidum (primary syphilis or chancre)
- Chlamydia trachomatis L1, L2 and L3 serovars causing lymphogranuloma venereum (LGV) (relatively uncommon in the U.S., but outbreaks, particularly in men who have sex with men, have been reported)
- Sexually Transmitted Infections which are very rare in the United States:
- Haemophilus ducreyi (chancroid)
- Klebsiella granulomatis (formerly Calymmatobacterium granulomatis) causing granuloma inguinale (donovanosis)
- Other infections which have been occasionally reported to cause genital ulcers:
- Primary HIV
- Phthirus pubis
- Sarcoptes scabei with pyoderma
- EBV
- Tuberculosis
- Entamoeba histolytica
- Monkeypox
- In 2022 an outbreak of monkeypox was reported, with some individuals noted to have genital ulcers, among other clinical features.
Non-Infectious Causes
- Trauma, fixed drug eruption, Behçets syndrome, malignancy, Crohn’s disease, Lipschutz ulcer
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PATHOGENS
Infectious Causes
- Common Sexually Transmitted Infections:
- Herpes simplex virus
- Treponema pallidum (primary syphilis or chancre)
- Chlamydia trachomatis L1, L2 and L3 serovars causing lymphogranuloma venereum (LGV) (relatively uncommon in the U.S., but outbreaks, particularly in men who have sex with men, have been reported)
- Sexually Transmitted Infections which are very rare in the United States:
- Haemophilus ducreyi (chancroid)
- Klebsiella granulomatis (formerly Calymmatobacterium granulomatis) causing granuloma inguinale (donovanosis)
- Other infections which have been occasionally reported to cause genital ulcers:
- Primary HIV
- Phthirus pubis
- Sarcoptes scabei with pyoderma
- EBV
- Tuberculosis
- Entamoeba histolytica
- Monkeypox
- In 2022 an outbreak of monkeypox was reported, with some individuals noted to have genital ulcers, among other clinical features.
Non-Infectious Causes
- Trauma, fixed drug eruption, Behçets syndrome, malignancy, Crohn’s disease, Lipschutz ulcer
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