Fluconazole

Edina Avdic, Pharm.D.
Fluconazole is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Candidiasis prophylaxis (patients undergoing bone marrow transplant who receive cytotoxic chemotherapy and/or radiation therapy)
  • Oropharyngeal and esophageal candidiasis
  • Vulvovaginal candidiasis
  • Cryptococcal meningitis (treatment and suppression)

NON-FDA APPROVED USES

  • Candida infections
    • Disseminated candidiasis and candidemia (including peritonitis)
    • Endophthalmitis
    • Osteoarticular infection and septic arthritis
    • UTIs
    • Endovascular - step-down therapy
    • CNS candidiasis - step-down therapy
    • Neonatal candidiasis
    • Prophylaxis: critically ill patients s/p GI surgery, candidal infection prevention
  • Coccidioidomycosis
  • Disseminated cryptococcosis
  • Histoplasmosis, blastomycosis: alternative therapy for mild to moderate diseases in patients intolerant to itraconazole.
  • Pityriasis versicolor

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Last updated: March 6, 2018