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Diloxanide furoate

Paul A. Pham, Pharm.D. BCPS, Kathryn Dzintars, Pharm.D., BCPS
Diloxanide furoate is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Drug not currently available for use in the U.S.
    • Also known as in the literature as entamide furoate or entamide.
  • CDC conducted a study with investigational use of the drug between 1977-1990.

NON-FDA APPROVED USES

  • Amebiasis limited to the GI lumen, caused by Entamoeba histolytica.
  • As combination therapy with other antiprotozoals such as nitroimidazoles for the treatment of invasive or extraintestinal amebiasis. Diloxanide furoate is not a tissue amoebicide and therefore in extraintestinal infections of E. histolytica, another agent (specifically a "tissue amoebicide" like Metronidazole) should be considered for use in combination with diloxanide furoate.

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Last updated: January 13, 2016

Citation

Pham, Paul A, and Kathryn Dzintars. "Diloxanide Furoate." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540198/all/Diloxanide_furoate.
Pham PA, Dzintars K. Diloxanide furoate. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540198/all/Diloxanide_furoate. Accessed March 24, 2019.
Pham, P. A., & Dzintars, K. (2016). Diloxanide furoate. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540198/all/Diloxanide_furoate
Pham PA, Dzintars K. Diloxanide Furoate [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 March 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540198/all/Diloxanide_furoate.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Diloxanide furoate ID - 540198 A1 - Pham,Paul,Pharm.D. BCPS AU - Dzintars,Kathryn,Pharm.D., BCPS Y1 - 2016/01/13/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540198/all/Diloxanide_furoate PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -