Diloxanide furoate

Paul A. Pham, Pharm.D. BCPS, Kathryn Dzintars, Pharm.D., BCPS
Diloxanide furoate is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Drug not currently available for use in the U.S.
    • Also known as in the literature as entamide furoate or entamide.
  • CDC conducted a study with investigational use of the drug between 1977-1990.

NON-FDA APPROVED USES

  • Amebiasis limited to the GI lumen, caused by Entamoeba histolytica.
  • As combination therapy with other antiprotozoals such as nitroimidazoles for the treatment of invasive or extraintestinal amebiasis. Diloxanide furoate is not a tissue amoebicide and therefore in extraintestinal infections of E. histolytica, another agent (specifically a "tissue amoebicide" like Metronidazole) should be considered for use in combination with diloxanide furoate.

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Last updated: January 13, 2016