Johns Hopkins ABX Guide
Doxycycline
INDICATIONS
FDA
FDA
- Acne vulgaris
- Adjunctive therapy if severe
- Amebiasis
- Adjunctive therapy
- Anthrax due to Bacillus anthracis
- Inhalation anthrax: Post-exposure prophylaxis or treatment (see "biodefense-anthrax")
- Treatment of cutaneous, gastrointestinal or oropharyngeal anthrax
- If PCN allergic
- Syphilis (Treponema pallidum)
- Yaws caused by Treponema pertenue
- Vincent’s infection (Fusobacterium nucleatum subsp fusiforme)
- Actinomycosis
- Infections caused by Clostridia species
- Relapsing fever caused by Borrelia recurrentis
- Respiratory infections
- Mycoplasma pneumonia
- Psittacosis caused by Chlamydia psittaci
- Infections when caused by the following bacteria with appropriate susceptibility
- Rickettsial infections
- Rocky Mountain spotted fever (RMSF), typhus, Q fever, rickettsialpox, and tick fevers caused by Rickettsia species.
- Sexually transmitted infections
- Uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis
- Nongonococcal urethritis caused by Ureaplasma urealyticum
- Lymphogranuloma venereum caused by Chlamydia spp.
- Granuloma inguinale caused by Calymmatobacterium granulomatis
- Trachoma, inclusion conjunctivitis caused by C. trachomatis.
- Gram-negative infections caused by Y. pestis, F. tularensis, V. cholerae, C. fetus, Brucella species,B. bacilliformis, C. granulomatis.
- And for other organisms, if susceptible: Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species
- Urinary tract infections caused by Klebsiella species
- Malaria
- Prophylaxis due to P. falciparumfor short-term (< 4 months) travelers to regions with chloroquine- and/or pyrimethamine-sulfadoxine-resistant strains.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Lyme disease
- Community-acquired pneumonia
- Acute bacterial rhinosinusitis
- Skin and soft tissue infections due to S. aureus
- Tularemia
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Last updated: May 11, 2025
Citation
Dzintars, Kathryn, and Paul G Auwaerter. "Doxycycline." Johns Hopkins ABX Guide, The Johns Hopkins University, 2025. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540178/all/Doxycycline.
Dzintars K, Auwaerter PG. Doxycycline. Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540178/all/Doxycycline. Accessed July 22, 2025.
Dzintars, K., & Auwaerter, P. G. (2025). Doxycycline. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540178/all/Doxycycline
Dzintars K, Auwaerter PG. Doxycycline [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. [cited 2025 July 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540178/all/Doxycycline.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Doxycycline
ID - 540178
A1 - Dzintars,Kathryn,Pharm.D., BCPS
AU - Auwaerter,Paul,M.D.
Y1 - 2025/05/11/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540178/all/Doxycycline
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
