Doxycycline

Kathryn Dzintars, Pharm.D., BCPS, Paul G. Auwaerter, M.D.

INDICATIONS

FDA

Acne vulgaris
- Adjunctive therapy if severe
Amebiasis
- Adjunctive therapy
Anthrax due to Bacillus anthracis
- Inhalation anthrax: Post-exposure prophylaxis or treatment (see "biodefense-anthrax")
- Treatment of cutaneous, gastrointestinal or oropharyngeal anthrax
If PCN allergic
- Syphilis (Treponema pallidum)
- Yaws caused by Treponema pertenue
- Vincent’s infection (Fusobacterium nucleatum subsp fusiforme)
- Actinomycosis
- Infections caused by Clostridia species
Relapsing fever caused by Borrelia recurrentis
Respiratory infections
- Mycoplasma pneumonia
- Psittacosis caused by Chlamydia psittaci
- Infections when caused by the following bacteria with appropriate susceptibility
  - H. influenzae
  - Klebsiellaspp.
  - S. pneumoniae
Rickettsial infections
- Rocky Mountain spotted fever (RMSF), typhus, Q fever, rickettsialpox, and tick fevers caused by Rickettsia species.
Sexually transmitted infections
- Uncomplicated urethral, endocervical or rectal infections caused by Chlamydia trachomatis
- Nongonococcal urethritis caused by Ureaplasma urealyticum
- Lymphogranuloma venereum caused by Chlamydia spp.
- Granuloma inguinale caused by Calymmatobacterium granulomatis
Trachoma, inclusion conjunctivitis caused by C. trachomatis.
Gram-negative infections caused by Y. pestis, F. tularensis, V. cholerae, C. fetus, Brucella species,B. bacilliformis, C. granulomatis.
- And for other organisms, if susceptible: Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species
- Urinary tract infections caused by Klebsiella species
Malaria
- Prophylaxis due to P. falciparumfor short-term (< 4 months) travelers to regions with chloroquine- and/or pyrimethamine-sulfadoxine-resistant strains.

NON-FDA APPROVED USES

Lyme disease
Community-acquired pneumonia
Acute bacterial rhinosinusitis
Skin and soft tissue infections due to S. aureus
Tularemia

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