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Bacterial Cystitis, Acute, Uncomplicated

Michael Melia, M.D.
Bacterial Cystitis, Acute, Uncomplicated is a topic covered in the Johns Hopkins ABX Guide.

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  • Uncomplicated UTI: >95% of these infections are due to single organism.
  • Culprit pathogens:
    • E. coli (75-95%)
      • Uropathogenic E. coli (UPEC) most likely to cause UTIs are groups B2 and D that have "fitness elements" providing them with advantage in extraintestinal niche.
    • Other Enterobacteriaceae (e.g., K. pneumoniae, P. mirabilis)
    • S. saprophyticus 
    • Uncommon pathogens: P. aeruginosa, Group D Streptococci
    • Rare pathogens: H. influenzae, M. tuberculosis, anaerobes, Salmonella, Shigella, adenovirus type 11, Ureaplasma, Mycoplasma, Enterococcus spp., Group B Streptococci
      • Enterococcus spp. and group B Streptococcus alone rarely cause uncomplicated cystitis (see excellent Hooton NEJM 2013 reference[3]).
        • These two organisms are recovered from midstream urine specimens of ~10% of women with cystitis, but are rarely (1%) also isolated from paired catheter urine specimens.

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Last updated: April 5, 2017


Melia, Michael. "Bacterial Cystitis, Acute, Uncomplicated." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis__Acute__Uncomplicated.
Melia M. Bacterial Cystitis, Acute, Uncomplicated. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis__Acute__Uncomplicated. Accessed April 21, 2019.
Melia, M. (2017). Bacterial Cystitis, Acute, Uncomplicated. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis__Acute__Uncomplicated
Melia M. Bacterial Cystitis, Acute, Uncomplicated [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 April 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis__Acute__Uncomplicated.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Bacterial Cystitis, Acute, Uncomplicated ID - 540046 A1 - Melia,Michael,M.D. Y1 - 2017/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540046/all/Bacterial_Cystitis__Acute__Uncomplicated PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -