Bacterial Cystitis, Acute, Uncomplicated
Michael Melia, M.D.
PATHOGENS
PATHOGENS
PATHOGENS
- Uncomplicated UTI: >95% of these infections are due to a single organism.
- Culprit pathogens:
- E. coli (75-95%)
- Groups B2 and D are most likely to cause UTIs. Uropathogenic E. coli (UPEC) have "fitness elements" that provide them with an advantage in this extraintestinal niche.
- Other Enterobacteriaceae (e.g., K. pneumoniae, P. mirabilis)
- S. saprophyticus
- Uncommon pathogens: P. aeruginosa, Group D Streptococci
- Rare pathogens: H. influenzae, M. tuberculosis, anaerobes, Salmonella, Shigella, adenovirus type 11, Ureaplasma, Mycoplasma, Enterococcus spp., Group B Streptococci
- Enterococcus spp. and group B Streptococcus alone rarely cause uncomplicated cystitis (see excellent Hooton NEJM 2013 reference[8]).
- These two organisms are recovered from midstream urine specimens of ~10% of women with cystitis but are rarely (1%) also isolated from paired catheter urine specimens.
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