Johns Hopkins ABX Guide
Aztreonam
INDICATIONS
FDA
FDA
- Aztreonam (parenteral) should only be used for the treatment of the following infections caused by susceptible Gram-negative bacteria:
- Complicated and uncomplicated UTI[11]
- Pneumonia[11]
- Septicemia[11]
- Skin and soft tissue infections[11]
- Intra-abdominal infections (in combination with metronidazole)[11]
- Gynecologic infections (in combination with anaerobic coverage)[11]
- Aztreonam (inhalation, CAYSTON®) should only be used to improve respiratory symptoms in CF patients at least 7 years of age with known P. aeruginosa colonization in the lungs with moderate-to-severe lung disease (FEV1 ≥25% and ≤75%).[8]
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Febrile neutropenia due to Gram-negative bacteria[10]
- Meningitis due to Gram-negative bacteria[13]
- Alternative therapy for treatment of Gram-negative infections in patients with severe penicillin allergies.[4]
- Combination therapy with ceftazidime/avibactam to treat resistant Gram-negative infections caused by metallo-β-lactamases producers and S. maltophilia. [2][3]
- As of February 2025, aztreonam is available as a combination regimen with avibactam (Emblaveo™).
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Last updated: November 15, 2025
Citation
Tsai, Y. Vivian, and Edina Avdic. "Aztreonam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2025. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540041/all/Aztreonam.
Tsai Y, Avdic E. Aztreonam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540041/all/Aztreonam. Accessed November 18, 2025.
Tsai, Y., & Avdic, E. (2025). Aztreonam. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540041/all/Aztreonam
Tsai Y, Avdic E. Aztreonam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. [cited 2025 November 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540041/all/Aztreonam.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Aztreonam
ID - 540041
A1 - Tsai,Y. Vivian,Pharm.D.
AU - Avdic,Edina,Pharm.D.
Y1 - 2025/11/15/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540041/all/Aztreonam
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
