Johns Hopkins ABX Guide
Atovaquone
INDICATIONS
FDA
FDA
- Prevention of Pneumocystis jirovecii pneumonia in patients who are intolerant to TMP/SMX
- Oral treatment of mild-to-moderate Pneumocystis jirovecii pneumonia (second or third line)
- Prevention and treatment of malaria (in combination with proguanil: see separate module)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Toxoplasmosis treatment alone (limited data with atovaquone 750 mg four times a day in adults)
- Toxoplasmosis treatment in combination with pyrimethamine or sulfadiazine
- Babesiosis (in combination with azithromycin)
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Last updated: February 21, 2026
Citation
, Caitlin Soto, PharmD, BCIDP, and Janessa M Smith. "Atovaquone." Johns Hopkins ABX Guide, The Johns Hopkins University, 2026. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540038/5.2/Atovaquone.
C, Smith JM. Atovaquone. Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540038/5.2/Atovaquone. Accessed February 23, 2026.
, C., & Smith, J. M. (2026). Atovaquone. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540038/5.2/Atovaquone
C, Smith JM. Atovaquone [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2026. [cited 2026 February 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540038/5.2/Atovaquone.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Atovaquone
ID - 540038
A1 - ,Caitlin Soto, PharmD, BCIDP,
AU - Smith,Janessa,Pharm.D., BCPS
Y1 - 2026/02/21/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540038/5.2/Atovaquone
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
