Atovaquone

Janessa M. Smith, Pharm.D., BCPS, Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID

INDICATIONS

FDA

Prevention of Pneumocystis jirovecii pneumonia in patients who are intolerant to TMP/SMX
Oral treatment of mild-to-moderate Pneumocystis jirovecii pneumonia (second or third line)
Prevention and treatment of malaria (in combination with proguanil: see separate module)

NON-FDA APPROVED USES

Toxoplasmosis treatment alone (limited data with atovaquone 750 mg four times a day in adults)
Toxoplasmosis treatment in combination with pyrimethamine or sulfadiazine
Babesiosis (in combination with azithromycin)

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