Johns Hopkins ABX Guide
Ampicillin + Sulbactam
INDICATIONS
FDA
FDA
- Gynecologic infections: by beta-lactamase-producing strains of E. coli and Bacteroides spp. (including B. fragilis).
- Intra-abdominal infections: by beta-lactamase-producing strains of E. coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
- Skin and soft tissue infections: by S. aureus (MSSA), E. coli, Klebsiella spp. (including K. pneumoniae), P. mirabilis, B. fragilis, Enterobacter spp., and A. calcoaceticus.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Epiglottitis (H. influenzae)
- Head and neck infections
- Hepatic abscess (consider in mild disease)
- Diabetic foot infection (w/ mild superficial ulcer)
- Aspiration pneumonia
- Community-acquired pneumonia
- Bite wounds (Eikenella corrodens, Pasteurella multocida)
- Culture-negative endocarditis or endocarditis caused by HACEK organisms
- Surgical prophylaxis
- Infections caused by Acinetobacter spp.
- NOTE: it is not recommended empirically for intra-abdominal infections due to high resistance rates to E. coli.
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Last updated: January 11, 2025
Citation
Kathryn Dzintars, Pharm.D., BCPS, and Edina Avdic. "Ampicillin + Sulbactam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2025. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam.
Kathryn Dzintars, Pharm.D., BCPS, Avdic E. Ampicillin + Sulbactam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam. Accessed November 4, 2025.
Kathryn Dzintars, Pharm.D., BCPS, & Avdic, E. (2025). Ampicillin + Sulbactam. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam
Kathryn Dzintars, Pharm.D., BCPS, Avdic E. Ampicillin + Sulbactam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2025. [cited 2025 November 04]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam.
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