Ampicillin + Sulbactam

Edina Avdic, Pharm.D.
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS

INDICATIONS

Gynecologic infections: by beta-lactamase-producing strains of E. coli and Bacteroides spp. (including B. fragilis).
Intra-abdominal infections: by beta-lactamase-producing strains of E. coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
Skin and soft tissue infections: by S. aureus (MSSA), E. coli, Klebsiella spp. (including K. pneumoniae), P. mirabilis, B. fragilis, Enterobacter spp., and A. calcoaceticus.

Epiglottitis (H. influenzae)
Head and neck infections
Hepatic abscess (consider in mild disease)
Diabetic foot infection (w/ mild superficial ulcer)
Aspiration pneumonia
Community-acquired pneumonia
Bite wounds (Eikenella corrodens, Pasteurella multocida)
Culture-negative endocarditis or endocarditis caused by HACEK organisms
Surgical prophylaxis
Infections caused by Acinetobacter spp.
NOTE: it is not recommended empirically for intra-abdominal infections due to high resistance rates to E. coli.

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