Ampicillin + Sulbactam
Kathryn Dzintars, Pharm.D., BCPS
,
Edina Avdic, Pharm.D.
Pediatric Dosing Author:
Bethany Sharpless Chalk, Pharm.D., BCPPS
INDICATIONS
INDICATIONS
INDICATIONS
FDA
FDA
FDA
Gynecologic infections: by beta-lactamase-producing strains of
E. coli
and
Bacteroides
spp.
(including
B. fragilis
).
Intra-abdominal infections
: by beta-lactamase-producing strains of
E. coli
,
Klebsiella
spp
. (including
K. pneumoniae
),
Bacteroides
spp. (including
B. fragilis
), and
Enterobacter
spp
.
Skin and soft tissue infections: by
S. aureus
(MSSA),
E. coli
,
Klebsiella
spp
. (including
K. pneumoniae
),
P. mirabilis
,
B. fragilis
,
Enterobacter
spp.
, and
A. calcoaceticus
.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
NON-FDA APPROVED USES
Epiglottitis
(
H. influenzae
)
Head and neck infections
Hepatic abscess
(consider in mild disease)
Diabetic foot infection
(w/ mild superficial ulcer)
Aspiration pneumonia
Community-acquired pneumonia
Bite wounds
(
Eikenella corrodens
,
Pasteurella multocida
)
Culture-negative endocarditis or endocarditis caused by HACEK organisms
Surgical prophylaxis
Infections caused by
Acinetobacter
spp.
NOTE: it is not recommended empirically for intra-abdominal infections due to high resistance rates to
E. coli
.
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