Johns Hopkins ABX Guide
Ampicillin + Sulbactam
Ampicillin + Sulbactam is a topic covered in the Johns Hopkins ABX Guide.
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INDICATIONS
FDA
FDA
- Gynecologic infections: by beta-lactamase producing strains of E. coli, and Bacteroides spp. (including B. fragilis).
- Intra-abdominal infections: by beta-lactamase producing strains of E. coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
- Skin and soft tissue infections: by S. aureus (MSSA), E. coli, Klebsiella spp. (including K. pneumoniae), P. mirabilis, B. fragilis, Enterobacter spp., and A. calcoaceticus.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Epiglottitis (H. influenzae)
- Head and neck infections
- Hepatic abscess (consider in mild disease)
- Diabetic foot infection (w/ mild superficial ulcer)
- Aspiration pneumonia
- Bite wounds (Eikenella corrodens, Pasteurella multocida)
- Culture negative endocarditis or endocarditis caused by HACEK organisms
- Surgical prophylaxis
- Infections caused by Acinetobacter spp.
- NOTE: it is not recommended empirically for intra-abdominal infections due to high rates of resistance to E. coli.
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INDICATIONS
FDA
FDA
- Gynecologic infections: by beta-lactamase producing strains of E. coli, and Bacteroides spp. (including B. fragilis).
- Intra-abdominal infections: by beta-lactamase producing strains of E. coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp.
- Skin and soft tissue infections: by S. aureus (MSSA), E. coli, Klebsiella spp. (including K. pneumoniae), P. mirabilis, B. fragilis, Enterobacter spp., and A. calcoaceticus.
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Epiglottitis (H. influenzae)
- Head and neck infections
- Hepatic abscess (consider in mild disease)
- Diabetic foot infection (w/ mild superficial ulcer)
- Aspiration pneumonia
- Bite wounds (Eikenella corrodens, Pasteurella multocida)
- Culture negative endocarditis or endocarditis caused by HACEK organisms
- Surgical prophylaxis
- Infections caused by Acinetobacter spp.
- NOTE: it is not recommended empirically for intra-abdominal infections due to high rates of resistance to E. coli.
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Last updated: September 3, 2016
Citation
Avdic, Edina, et al. "Ampicillin + Sulbactam." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam.
Avdic E, Pham PA, Jenh Hsu A. Ampicillin + Sulbactam. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam. Accessed January 23, 2020.
Avdic, E., Pham, P. A., & Jenh Hsu, A. (2016). Ampicillin + Sulbactam. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam
Avdic E, Pham PA, Jenh Hsu A. Ampicillin + Sulbactam [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2020 January 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Ampicillin + Sulbactam
ID - 540024
A1 - Avdic,Edina,Pharm.D.
AU - Pham,Paul,Pharm.D.
AU - Jenh Hsu,Alice,Pharm.D.
Y1 - 2016/09/03/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540024/all/Ampicillin_+_Sulbactam
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -