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Transient Erythroblastopenia of Childhood

Transient Erythroblastopenia of Childhood is a topic covered in the 5-Minute Pediatric Consult.

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Basics

Description

An acquired, self-limited suppression of red cell production in an otherwise healthy child

Epidemiology

  • Mean age at diagnosis is 26 months.
  • <10% are >3 years of age at diagnosis.
  • Slight male predominance (male/female 5.1:3.1)
  • No seasonal predominance

Incidence

The incidence of transient erythroblastopenia of childhood is unknown due to limited data about unreported asymptomatic cases.

Risk Factors

Genetics

  • There is no simple genetic pattern.
  • Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.

General Prevention

There is no known way to prevent transient erythroblastopenia of childhood.

Pathophysiology

Transient erythroblastopenia of childhood is due to the absence of red cell precursors in bone marrow.

Etiology

  • Unknown
  • Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
  • A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.

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Citation

Cabana, Michael D., editor. "Transient Erythroblastopenia of Childhood." 5-Minute Pediatric Consult, 8th ed., Wolters Kluwer, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617423/all/Transient_Erythroblastopenia_of_Childhood.
Transient Erythroblastopenia of Childhood. In: Cabana MD, ed. 5-Minute Pediatric Consult. 8th ed. Wolters Kluwer; 2019. https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617423/all/Transient_Erythroblastopenia_of_Childhood. Accessed April 23, 2019.
Transient Erythroblastopenia of Childhood. (2019). In Cabana, M. D. (Ed.), 5-Minute Pediatric Consult. Available from https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617423/all/Transient_Erythroblastopenia_of_Childhood
Transient Erythroblastopenia of Childhood [Internet]. In: Cabana MD, editors. 5-Minute Pediatric Consult. Wolters Kluwer; 2019. [cited 2019 April 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617423/all/Transient_Erythroblastopenia_of_Childhood.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Transient Erythroblastopenia of Childhood ID - 617423 ED - Cabana,Michael D, BT - 5-Minute Pediatric Consult UR - https://peds.unboundmedicine.com/pedscentral/view/5-Minute-Pediatric-Consult/617423/all/Transient_Erythroblastopenia_of_Childhood PB - Wolters Kluwer ET - 8 DB - Pediatrics Central DP - Unbound Medicine ER -