Transient Erythroblastopenia of Childhood
Basics
Basics
Basics
Description
Description
Description
An acquired, self-limited suppression of red cell production in an otherwise healthy child
Epidemiology
Epidemiology
Epidemiology
- Mean age at diagnosis is 26 months.
- <10% are >3 years of age at diagnosis.
- Slight male predominance (male/female 5.1:3.1)
- No seasonal predominance
Incidence
Incidence
Incidence
The incidence of transient erythroblastopenia of childhood is unknown due to limited data about unreported asymptomatic cases.
Risk Factors
Risk Factors
Risk Factors
Genetics
Genetics
Genetics
- There is no simple genetic pattern.
- Familial transient erythroblastopenia of childhood has been reported (rarely), suggesting a combination of environmental factors and genetic propensity.
General Prevention
General Prevention
General Prevention
There is no known way to prevent transient erythroblastopenia of childhood.
Pathophysiology
Pathophysiology
Pathophysiology
Transient erythroblastopenia of childhood is due to the absence of red cell precursors in bone marrow.
Etiology
Etiology
Etiology
- Unknown
- Possible viral causes include parvovirus B19 and human herpesvirus 6 (HHV-6), but this remains hypothetical.
- A serum inhibitor, such as an IgG directed at the committed erythroid stem cell progenitor, has also been proposed but not yet proven.
There's more to see -- the rest of this topic is available only to subscribers.
© 2000–2025 Unbound Medicine, Inc. All rights reserved