Kathryn Dzintars, Pharm.D., BCPS



  • Ibrexafungerp is indicated for the treatment of vulvovaginal candidiasis (VVC) in adults and post-menarchal pediatric females.
  • On September 27, 2023, SCYNEXIS issued a voluntary recall of ibrexfungerp tablets due to cross-contamination with a non-antibacterial beta-lactam drug substance.
    • At the time of this update, contamination concerns are still ongoing.
    • A phase 3, randomized, double-blind study for patients with invasive candidiasis treated with an IV echinocandin followed by either ibrexafungerp or oral fluconazole (MARIO; NCT05178862) was suspended due to this contamination risk. It is unlikely this phase 3 study will re-open.

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Last updated: May 10, 2024