Cardiobacterium species

Cardiobacterium species is a topic covered in the Johns Hopkins ABX Guide.

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  • Gram-negative bacillus, aerobic, on staining may be highly pleomorphic.
    • Part of upper respiratory human flora and occasionally on oral mucosal surfaces, it can be recovered in 70% of normal people.
    • Catalase-negative, oxidase-positive, indole-positive.
    • Slow-growing in traditional media
    • Low-virulence organism
    • Member of HACEK group that may cause endocarditis
  • Major species: Cardiobacterium hominis is the most common human pathogen species, through remains a rare infection overall.
    • Other species:
      • C. valvarum 
    • MALDI-ToF has been helpful at improving proper microbiologic identification.
  • Traditionally, a penicillin-sensitive organism, though in recent years, beta-lactamase production described in some isolates.
    • Aminoglycosides and fluoroquinolones also usually active.

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Last updated: April 5, 2019