Aggregatibacter species
MICROBIOLOGY
- Aggregatibacter spp. are normal residents of human oropharyngeal flora (especially dental plaques and gingiva), sometimes urogenital flora.
- Member of Pasteurellaceae family.
- Member of Pasteurellaceae family.
- Aggregatibacter actinomycetemcomitans (Aa) is a facultative Gram-negative, slowly growing coccobacillus.
- Formerly known as Actinobacillus actinomycetemcomitans, a member of the HACEK group.
- Earlier literature called the organism Haemophilus actinomycetemcomitans.
- Earlier literature called the organism Haemophilus actinomycetemcomitans.
- Original name due to descriptions of infections with actinomycotic-like presentations.
- When isolated in an abscess, almost always found in conjunction with Actinomyces spp.
- Generally easily isolated, but a slow grower and may need > 7d incubation.
- The most common cause of Aggregatibacter endocarditis.
- Implicated in periodontitis and gingivitis.
- Formerly known as Actinobacillus actinomycetemcomitans, a member of the HACEK group.
- A. aphrophilus: formerly Haemophilus aphrophilus [Fig], is the second most common cause of Aggregatibacter endocarditis.
- Most common in this group to be the cause of a brain abscess.
- A. paraphrophilus: formerly Haemophilus paraphrophilus, a less common cause of endocarditis of this species (usually mitral valve), may also cause brain abscess.
- Also found in the GI tract.
- A. segnis: uncommon commensal in the oropharynx, a rare cause of endocarditis, bacteremia.
- A. urae: meningitis reported.
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Last updated: April 11, 2024
Citation
Auwaerter, Paul G. "Aggregatibacter Species." Johns Hopkins ABX Guide, The Johns Hopkins University, 2024. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species.
Auwaerter PG. Aggregatibacter species. Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species. Accessed December 3, 2024.
Auwaerter, P. G. (2024). Aggregatibacter species. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species
Auwaerter PG. Aggregatibacter Species [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. [cited 2024 December 03]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540669/all/Aggregatibacter_species.
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