BK Virus

Shmuel Shoham, M.D.
BK Virus is a topic covered in the Johns Hopkins ABX Guide.

To view the entire topic, please or .

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

-- The first section of this topic is shown below --

MICROBIOLOGY

  • DNA polyomavirus, first isolated in 1971 from the urine of a renal transplant patient with ureteral stenosis whose initials were B.K.
  • Other members of the polyomavirus family:
    • JC virus, ~75% information shared genomically, KI polyomavirus, WU polyomavirus and trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus.
  • Important viral components are large tumor antigen (T antigen), small tumor antigen (t antigen) and capsid proteins (VP1, VP2, VP3 and agnoprotein)
  • Subtypes: Subtype 1 is the most common, followed by subtype 4. Subtypes 3 and 4 are much less common. Serostatus of donor and recipient may impact risk for viral reactivation in kidney transplant.
    • PCR is best suited for detecting subtype 1. Some subtype 3 and 4 isolates have polymorphisms that may impact their detection, leading to falsely low viral load measurements

-- To view the remaining sections of this topic, please or --

MICROBIOLOGY

  • DNA polyomavirus, first isolated in 1971 from the urine of a renal transplant patient with ureteral stenosis whose initials were B.K.
  • Other members of the polyomavirus family:
    • JC virus, ~75% information shared genomically, KI polyomavirus, WU polyomavirus and trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus.
  • Important viral components are large tumor antigen (T antigen), small tumor antigen (t antigen) and capsid proteins (VP1, VP2, VP3 and agnoprotein)
  • Subtypes: Subtype 1 is the most common, followed by subtype 4. Subtypes 3 and 4 are much less common. Serostatus of donor and recipient may impact risk for viral reactivation in kidney transplant.
    • PCR is best suited for detecting subtype 1. Some subtype 3 and 4 isolates have polymorphisms that may impact their detection, leading to falsely low viral load measurements

There's more to see -- the rest of this topic is available only to subscribers.

Last updated: January 14, 2023