Artemether/Lemefantrine

Edina Avdic, Pharm.D.
Artemether/Lemefantrine is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum in patients with ≥ 5 kg.
    • Manufacturer does not recommend use for the treatment of severe malaria or the prevention of P. falciparum malaria.
    • Most recent CDC guidelines recommend artemether/lumefantrine use for the treatment of severe malaria following administration of IV artesunate or while waiting for IV artesunate to arrive from CDC (see CDC website)

NON-FDA APPROVED USES

  • Treatment of severe malaria due to P. falciparum following administration of IV artesunate or while awaiting for IV artesunate to arrive from CDC.
  • Treatment of uncomplicated P. vivax malaria (2015 WHO recommendations)[2].

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INDICATIONS

FDA

  • Treatment of acute, uncomplicated malaria infections due to Plasmodium falciparum in patients with ≥ 5 kg.
    • Manufacturer does not recommend use for the treatment of severe malaria or the prevention of P. falciparum malaria.
    • Most recent CDC guidelines recommend artemether/lumefantrine use for the treatment of severe malaria following administration of IV artesunate or while waiting for IV artesunate to arrive from CDC (see CDC website)

NON-FDA APPROVED USES

  • Treatment of severe malaria due to P. falciparum following administration of IV artesunate or while awaiting for IV artesunate to arrive from CDC.
  • Treatment of uncomplicated P. vivax malaria (2015 WHO recommendations)[2].

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Last updated: June 6, 2019