Vibrio species (non-cholera)
MICROBIOLOGY
- Aerobic, Gram-negative, comma-shaped rod (1-3 x 0.5-0.8µm, Fig).
- Grows best in warm, low-salinity marine water. Coastal waters/estuaries are ideal. As marine environments warm, these organisms have spread to new areas (e.g., northern coastal states) and are increasingly important causes of human infections.
- Rates of infections in the U.S. have tripled over the past two decades. Estimated to cause approximately 80,000 cases and 100 deaths each year (most are not laboratory-confirmed).
- The most important non-cholera species are V. parahaemolyticus (most cases), V. alginolyticus (second most cases), and V. vulnificus (most dangerous with ~20% or higher mortality).
- Vibrio parahaemolyticus:
- The most common non-cholera vibrio to cause infections.
- Typical presentations:
- GI disease: diarrhea associated with consumption of contaminated fish/seafood.
- It can also cause skin infections from exposure to open wounds to seawater.
- Most environmental strains are non-pathogenic.
- Pathogenic strains carry a hemolysin toxin: thermostable direct hemolysin (TDH) and/or TDH-related hemolysin (TRH).
- Strains with TDH cause hemolysis on special blood agar plates (Kanagawa reaction).
- Vibrio vulnificus is less common but more lethal. This organism is related to 95% of seafood-associated mortality.
- It is part of the normal microbial ecology of estuarine water and mollusks (e.g., in the Chesapeake Bay and areas of the coast off the Gulf of Mexico).
- Infection can be acquired via direct inoculation into skin/soft tissues or ingesting raw or undercooked seafood (~10% of cases).
- There are three recognized biotypes, of which biotype 1 is the most important cause of human infection.
- Important toxins are collagenases, metalloproteinases, and lipases/phospholipases, which lead to tissue destruction, and endotoxin, which leads to hypotension and organ failure.
- Vibrio alginolyticus:
- An emerging pathogen typically impacts people in coastal communities.
- Causes about 20% of vibriosis.
- Non-foodborne infections predominate (~86%) and typically affect lower extremity skin or external ears after swimming in warm coastal waters.
- An emerging pathogen typically impacts people in coastal communities.
- Other occasional Vibrio species causing human infection: V. fluvialis, V. fumissii, V. hollisae, V. damsela, V. cincinnatiensis.
- V. cholerae causes cholera (see that module for details)
- Vibrio parahaemolyticus:
- Diagnosis:
- Culture:
- Obtain from suspected source, e.g., blood (sepsis), wound (wound infection), stool (gastroenteritis).
- Organisms grow well on routine media and in blood cultures.
- Notify the micro lab if it is suspected to cause gastroenteritis and use special selective media for stool specimens such as thiosulfate citrate bile salt sucrose (TCBS).
- Some labs in endemic areas routinely use this media as part of stool culture protocol during summertime/warmer weather.
- Molecular:
- The diagnosis of GI illness due to V. parahaemolyticus is increasingly made via non-culture-based (e.g., molecular) assays as part of a multiplex panel.
- Culture:
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Last updated: August 7, 2024
Citation
Shoham, Shoham. "Vibrio Species (non-cholera)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2024. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540586/4/Vibrio_species__non_cholera_.
Shoham S. Vibrio species (non-cholera). Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540586/4/Vibrio_species__non_cholera_. Accessed October 10, 2024.
Shoham, S. (2024). Vibrio species (non-cholera). In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540586/4/Vibrio_species__non_cholera_
Shoham S. Vibrio Species (non-cholera) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2024. [cited 2024 October 10]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540586/4/Vibrio_species__non_cholera_.
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