Varicella Zoster- Hyperimmune globulin
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INDICATIONS
FDA
- VZV post-exposure prophylaxis in high-risk individuals:
- Immunocompromised children and adults
- Newborns of mothers with varicella around the time of delivery
- Premature infants
- Infants < 1 year of age
- Adults without evidence of the immunity
- Pregnant women
- ACIP and AAP recommend administration of VariZIG as soon as possible after exposure and within 10 days[1]
- The ACIP and AAP recommendations for post-exposure prophylaxis:
- Immunocompromised patients without evidence of immunity.
- Newborn infants whose mothers have signs and symptoms of varicella around the time of delivery (i.e., 5 days before to 2 days after delivery).
- Hospitalized premature infants born at ≥ 28 weeks of gestation whose mothers do not have evidence of immunity to varicella.
- Hospitalized premature infants born at < 28 weeks of gestation or who weigh ≤1000 g at birth, regardless of their mother’s evidence of immunity to varicella.
- Pregnant women without evidence of immunity.
- The ACIP and AAP recommendations for post-exposure prophylaxis:
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INDICATIONS
FDA
- VZV post-exposure prophylaxis in high-risk individuals:
- Immunocompromised children and adults
- Newborns of mothers with varicella around the time of delivery
- Premature infants
- Infants < 1 year of age
- Adults without evidence of the immunity
- Pregnant women
- ACIP and AAP recommend administration of VariZIG as soon as possible after exposure and within 10 days[1]
- The ACIP and AAP recommendations for post-exposure prophylaxis:
- Immunocompromised patients without evidence of immunity.
- Newborn infants whose mothers have signs and symptoms of varicella around the time of delivery (i.e., 5 days before to 2 days after delivery).
- Hospitalized premature infants born at ≥ 28 weeks of gestation whose mothers do not have evidence of immunity to varicella.
- Hospitalized premature infants born at < 28 weeks of gestation or who weigh ≤1000 g at birth, regardless of their mother’s evidence of immunity to varicella.
- Pregnant women without evidence of immunity.
- The ACIP and AAP recommendations for post-exposure prophylaxis:
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