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Varicella Zoster- Hyperimmune globulin

Edina Avdic, Pharm.D., Paul A. Pham, Pharm.D.
Pediatric Dosing Author: Alice Jenh Hsu, PharmD, BCPS, AQ-ID
Varicella Zoster- Hyperimmune globulin is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • VZV post-exposure prophylaxis in high-risk individuals:
    • Immunocompromised children and adults
    • Newborns of mothers with varicella around the time of delivery
    • Premature infants
    • Infants < 1 year of age
    • Adults without evidence of the immunity
    • Pregnant women
  • ACIP and AAP recommend administration of VariZIG as soon as possible after exposure and within 10 days[1]
    • The ACIP and AAP recommendations for post-exposure prophylaxis:
      • Immunocompromised patients without evidence of immunity.
      • Newborn infants whose mothers have signs and symptoms of varicella around the time of delivery (i.e., 5 days before to 2 days after delivery).
      • Hospitalized premature infants born at ≥ 28 weeks of gestation whose mothers do not have evidence of immunity to varicella.
      • Hospitalized premature infants born at < 28 weeks of gestation or who weigh ≤1000 g at birth, regardless of their mother’s evidence of immunity to varicella.
      • Pregnant women without evidence of immunity.

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Last updated: March 7, 2019

Citation

Avdic, Edina, and Paul A Pham. "Varicella Zoster- Hyperimmune Globulin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540581/all/Varicella_Zoster__Hyperimmune_globulin.
Avdic E, Pham PA. Varicella Zoster- Hyperimmune globulin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540581/all/Varicella_Zoster__Hyperimmune_globulin. Accessed April 19, 2019.
Avdic, E., & Pham, P. A. (2019). Varicella Zoster- Hyperimmune globulin. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540581/all/Varicella_Zoster__Hyperimmune_globulin
Avdic E, Pham PA. Varicella Zoster- Hyperimmune Globulin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 April 19]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540581/all/Varicella_Zoster__Hyperimmune_globulin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Varicella Zoster- Hyperimmune globulin ID - 540581 A1 - Avdic,Edina,Pharm.D. AU - Pham,Paul,Pharm.D. Y1 - 2019/03/07/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540581/all/Varicella_Zoster__Hyperimmune_globulin PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -