Johns Hopkins ABX Guide
Tropheryma whipplei
MICROBIOLOGY
- Agent of Whipple’s disease (WD), distant relationship to actinomyces by 16s rDNA sequencing.
- Detected in multiple environmental samples, including soil and sewerage. Considered ubiquitous.
- Fastidious organism, 0.25µm rods may appear Gram-positive upon staining.
- Has a characteristic trilaminar cell membrane on electron microscopy [Fig 1].
- Correct nomenclature: Tropheryma whipplei (not T. whippelii).
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Last updated: February 4, 2023
Citation
Auwaerter, Paul. "Tropheryma Whipplei." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540566/all/Tropheryma_whipplei.
Auwaerter P. Tropheryma whipplei. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540566/all/Tropheryma_whipplei. Accessed May 6, 2025.
Auwaerter, P. (2023). Tropheryma whipplei. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540566/all/Tropheryma_whipplei
Auwaerter P. Tropheryma Whipplei [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2025 May 06]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540566/all/Tropheryma_whipplei.
* Article titles in AMA citation format should be in sentence-case
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