Tobramycin
INDICATIONS
FDA
FDA
- UTI
- Septicemia, including serious central nervous system infections (use in combination)
- Lower respiratory tract infections (use in combination)
- Complicated urinary tract infections
- Intra-abdominal infections, including peritonitis (use in combination)
- Skin, bone, and skin structure infections (use in combination)
- Management of cystic fibrosis with P. aeruginosa (as tobramycin inhalation)
- Safety and efficacy have not been demonstrated in patients under the age of six years, patients with a forced expiratory volume in less than one second (FEV1) less than 40% or greater than 80% predicted, or patients colonized with Burkholderia cepacia.
- Treatment of ocular infections (uncomplicated conjunctivitis-ophthalmic solution)
NON-FDA APPROVED USES
NON-FDA APPROVED USES
- Pneumonia, hospital-acquired (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, or a third-/fourth-generation cephalosporin)
- Considered in patients with MDR gram negative infections.
- Efficacy is unproven.
- Pseudomonal infections (in combination with a beta-lactam, beta-lactam/beta-lactamase inhibitor, carbapenem or a third/fourth-generation cephalosporin)
- Bronchiectasis, non-cystic fibrosis (inhaled)
- Otitis external (tobramycin/dexamethasone topical)
There's more to see -- the rest of this topic is available only to subscribers.
Last updated: July 16, 2023
Citation
Auwaerter, Paul G, and Paul A Pham. "Tobramycin." Johns Hopkins ABX Guide, The Johns Hopkins University, 2023. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540556/all/Tobramycin.
Auwaerter PG, Pham PA. Tobramycin. Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540556/all/Tobramycin. Accessed October 6, 2024.
Auwaerter, P. G., & Pham, P. A. (2023). Tobramycin. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540556/all/Tobramycin
Auwaerter PG, Pham PA. Tobramycin [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2023. [cited 2024 October 06]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540556/all/Tobramycin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Tobramycin
ID - 540556
A1 - Auwaerter,Paul,M.D.
AU - Pham,Paul,Pharm.D.
Y1 - 2023/07/16/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540556/all/Tobramycin
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -