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    Streptococcus pyogenes (Group A)

    John G. Bartlett, M.D.
    Streptococcus pyogenes (Group A) is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar.
      • Streptococcus pyogenes, Lancefield group A.
      • Gram-positive cocci in chains.
    • Ecologic niche is pharynx, colonization rates:
      • Adults 2-3%
      • School children 15-20%
    • Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
      • M protein gene (emm) ~100 serotypes
        • May be used to track outbreaks, public health tracking of invasive infections
        • Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.
    • See Streptococcus species module for non-GAS strep organisms or S. pneumoniae.

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    Last updated: November 8, 2016

    Citation

    Bartlett, John G. "Streptococcus Pyogenes (Group A)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
    Bartlett JG. Streptococcus pyogenes (Group A). Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_. Accessed March 24, 2019.
    Bartlett, J. G. (2016). Streptococcus pyogenes (Group A). In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_
    Bartlett JG. Streptococcus Pyogenes (Group A) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 March 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Streptococcus pyogenes (Group A) ID - 540524 A1 - Bartlett,John,M.D. Y1 - 2016/11/08/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_ PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -