Johns Hopkins ABX Guide
Streptococcus pyogenes (Group A)
Streptococcus pyogenes (Group A) is a topic covered in the Johns Hopkins ABX Guide.
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MICROBIOLOGY
- Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar. See Streptococcal species or S. pneumoniae modules for other streptococci.
- Streptococcus pyogenes, Lancefield group A.
- Gram-positive cocci in chains [Fig 1].
- Ecologic niches are pharynx, genital mucosa and skin; colonization rates:
- Adults 2-3%
- School children 15-20%
- Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
- M protein gene (emm) ~100 serotypes
- May be used to track outbreaks, public health tracking of invasive infections
- Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.
- M protein gene (emm) ~100 serotypes
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Last updated: August 9, 2019
Citation
Auwaerter, Paul G, and John G Bartlett. "Streptococcus Pyogenes (Group A)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
Auwaerter PG, Bartlett JG. Streptococcus pyogenes (Group A). Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_. Accessed October 19, 2019.
Auwaerter, P. G., & Bartlett, J. G. (2019). Streptococcus pyogenes (Group A). In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_
Auwaerter PG, Bartlett JG. Streptococcus Pyogenes (Group A) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 October 19]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_.
* Article titles in AMA citation format should be in sentence-case
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T1 - Streptococcus pyogenes (Group A)
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AU - Bartlett,John,M.D.
Y1 - 2019/08/09/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540524/all/Streptococcus_pyogenes__Group_A_
PB - The Johns Hopkins University
DB - Pediatrics Central
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