Streptococcus pyogenes (Group A)
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MICROBIOLOGY
- Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar. See Streptococcal species or S. pneumoniae modules for other streptococci.
- Streptococcus pyogenes, Lancefield group A.
- Gram-positive cocci in chains [Fig 1].
- Ecologic niches are pharynx, genital mucosa and skin; colonization rates:
- Adults 2-3%
- School children 15-20%
- Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
- M protein gene (emm) ~100 serotypes
- May be used to track outbreaks, public health tracking of invasive infections
- Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.
- M protein gene (emm) ~100 serotypes
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MICROBIOLOGY
- Group A Streptococcus (GAS), beta-hemolytic--grows on blood agar. See Streptococcal species or S. pneumoniae modules for other streptococci.
- Streptococcus pyogenes, Lancefield group A.
- Gram-positive cocci in chains [Fig 1].
- Ecologic niches are pharynx, genital mucosa and skin; colonization rates:
- Adults 2-3%
- School children 15-20%
- Virulence depends on proteins that represent toxins, mimic host macromolecules and after immune responses.
- M protein gene (emm) ~100 serotypes
- May be used to track outbreaks, public health tracking of invasive infections
- Certain types (emm1, emm3, emm4, emm6, emm12, emm18, emm89) associated with most cases of invasive infections.
- M protein gene (emm) ~100 serotypes
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