Johns Hopkins ABX Guide
Sepsis
Sepsis is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Sepsis (Greek, putrefaction): life-threatening organ dysfunction caused by host response to infection.[22]
- Septic shock: a subset of sepsis in which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than sepsis alone.[4]
- Risk of sepsis is associated with both virulence of pathogen and immunologic vulnerabilities of host.
- Pathogens are associated with site of antecedent infection: not comprehensive list
- Gram-negative bacteria: E. coli, Klebsiella, Enterobacter, Pseudomonas, Serratia
- Gram-positive bacteria: Staphylococcus aureus, S. pneumoniae, Streptococcus species
- Toxin mediated: Staphylococcal or streptococcal toxic shock, Clostridium difficile, Clostridium sordellii.[18]
- Viral: influenza A, human metapneumovirus, coronavirus, and respiratory syncytial virus[7]
- Fungal: candida
- Rickettsial: R. rickettsii, R. typhi[14]
- Consider both (1) hosts with recognized vulnerabilities and (2) exposures to pathogens of recognized virulence.
- Maternal and neonatal: Group B streptococci, E. coli., Group A streptococci (puerperal sepsis)[12]
- Injection drug users: S. aureus, esp. MRSA, and Candida[8]
- Splenectomized or functionally asplenic pts: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Capnocytophaga canimorsus[9],Babesia spp.
- Neutropenic: GNB, Aspergillus.
- Traveler: malaria, salmonellosis.
- Healthy young adult: toxic shock syndromes (S. aureus or group A strep), N. meningitidis, bioterrorism (anthrax, plague), Hantavirus, severe influenza +/- bacterial superinfection.
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PATHOGENS
- Sepsis (Greek, putrefaction): life-threatening organ dysfunction caused by host response to infection.[22]
- Septic shock: a subset of sepsis in which underlying circulatory, cellular, and metabolic abnormalities are associated with a greater risk of mortality than sepsis alone.[4]
- Risk of sepsis is associated with both virulence of pathogen and immunologic vulnerabilities of host.
- Pathogens are associated with site of antecedent infection: not comprehensive list
- Gram-negative bacteria: E. coli, Klebsiella, Enterobacter, Pseudomonas, Serratia
- Gram-positive bacteria: Staphylococcus aureus, S. pneumoniae, Streptococcus species
- Toxin mediated: Staphylococcal or streptococcal toxic shock, Clostridium difficile, Clostridium sordellii.[18]
- Viral: influenza A, human metapneumovirus, coronavirus, and respiratory syncytial virus[7]
- Fungal: candida
- Rickettsial: R. rickettsii, R. typhi[14]
- Consider both (1) hosts with recognized vulnerabilities and (2) exposures to pathogens of recognized virulence.
- Maternal and neonatal: Group B streptococci, E. coli., Group A streptococci (puerperal sepsis)[12]
- Injection drug users: S. aureus, esp. MRSA, and Candida[8]
- Splenectomized or functionally asplenic pts: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Capnocytophaga canimorsus[9],Babesia spp.
- Neutropenic: GNB, Aspergillus.
- Traveler: malaria, salmonellosis.
- Healthy young adult: toxic shock syndromes (S. aureus or group A strep), N. meningitidis, bioterrorism (anthrax, plague), Hantavirus, severe influenza +/- bacterial superinfection.
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Last updated: September 5, 2019
Citation
Spacek, Lisa A. "Sepsis." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540497/all/Sepsis_.
Spacek LA. Sepsis. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540497/all/Sepsis_. Accessed November 30, 2021.
Spacek, L. A. (2019). Sepsis. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540497/all/Sepsis_
Spacek LA. Sepsis [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2021 November 30]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540497/all/Sepsis_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Sepsis
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A1 - Spacek,Lisa,M.D., Ph.D.
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BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540497/all/Sepsis_
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
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