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    Rhinovirus

    Paul Auwaerter, M.D.
    Rhinovirus is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Single-strand, non-enveloped positive sense RNA virus; member of the Picornaviridae family of viruses.
    • Over 105 serologic virus types. Human rhinovirus responsible for up to 0-80% of common colds.
      • Species include RV-A (adults > children), RV-B (least common) and RV-C (new species, often more severe or disseminated in children)
    • Rhinoviruses gain entry via the upper respiratory tract binding to ICAM-1 (intracellular adhesion molecule -1) receptors on epithelial cells lining the respiratory tract. Chemokines and cytokines cause inflammation as a consequence of viral infection causing local symptoms.
      • Involvement of cell receptor believed to account for part of host effect and and pathogenesis.

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    Last updated: February 1, 2016

    Citation

    Auwaerter, Paul. "Rhinovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540476/all/Rhinovirus.
    Auwaerter P. Rhinovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540476/all/Rhinovirus. Accessed April 18, 2019.
    Auwaerter, P. (2016). Rhinovirus. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540476/all/Rhinovirus
    Auwaerter P. Rhinovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2019 April 18]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540476/all/Rhinovirus.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Rhinovirus ID - 540476 A1 - Auwaerter,Paul,M.D. Y1 - 2016/02/01/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540476/all/Rhinovirus PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -