Johns Hopkins ABX Guide
Pyrimethamine
INDICATIONS
FDA
FDA
- Malaria (acute) in combination with sulfadoxine and quinine in the treatment of chloroquine-resistant Plasmodium falciparum malaria.
- Resistance prevalent worldwide; not recommended as a prophylactic agent for travelers to most areas (not available in US).
- Toxoplasmosis (in combination with sulfadiazine OR clindamycin plus leucovorin).
Non-FDA approved uses
Non-FDA approved uses
- Isospora
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Last updated: October 28, 2017
Citation
Smith, Janessa M, and Paul A Pham. "Pyrimethamine." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540462/all/Pyrimethamine.
Smith JM, Pham PA. Pyrimethamine. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540462/all/Pyrimethamine. Accessed July 23, 2025.
Smith, J. M., & Pham, P. A. (2017). Pyrimethamine. In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540462/all/Pyrimethamine
Smith JM, Pham PA. Pyrimethamine [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2025 July 23]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540462/all/Pyrimethamine.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Pyrimethamine
ID - 540462
A1 - Smith,Janessa,PharmD, BCPS
AU - Pham,Paul,Pharm.D.
Y1 - 2017/10/28/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540462/all/Pyrimethamine
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
