Johns Hopkins ABX Guide
Prion Diseases
Prion Diseases is a topic covered in the Johns Hopkins ABX Guide.
To view the entire topic, please sign in or purchase a subscription.
Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:
-- The first section of this topic is shown below --
PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
There's more to see -- the rest of this entry is available only to subscribers.
Last updated: January 12, 2020
Citation
Crowell, Trevor A. "Prion Diseases." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
Crowell TA. Prion Diseases. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases. Accessed September 25, 2020.
Crowell, T. A. (2020). Prion Diseases. In Johns Hopkins ABX Guide. The Johns Hopkins University. Retrieved September 25, 2020, from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases
Crowell TA. Prion Diseases [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2020 September 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Prion Diseases
ID - 540451
A1 - Crowell,Trevor,M.D.
Y1 - 2020/01/12/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
