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Prion Diseases

Trevor A. Crowell, M.D.
Prion Diseases is a topic covered in the Johns Hopkins ABX Guide.

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PATHOGENS

  • Prions are abnormally folded versions of cell membrane proteins which are otherwise normally found throughout the human body.
    • Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemical and physical methods of inactivation.
    • Can induce conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
  • Prions cause transmissible spongiform encephalopathies (TSEs).

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Last updated: December 2, 2015

Citation

Crowell, Trevor A. "Prion Diseases." Johns Hopkins ABX Guide, The Johns Hopkins University, 2015. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
Crowell TA. Prion Diseases. Johns Hopkins ABX Guide. The Johns Hopkins University; 2015. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases. Accessed April 22, 2019.
Crowell, T. A. (2015). Prion Diseases. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases
Crowell TA. Prion Diseases [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2015. [cited 2019 April 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Prion Diseases ID - 540451 A1 - Crowell,Trevor,M.D. Y1 - 2015/12/02/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -