Johns Hopkins ABX Guide
Prion Diseases
Prion Diseases is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins which are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemical and physical methods of inactivation.
- Can induce conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
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Last updated: December 2, 2015
Citation
Crowell, Trevor A. "Prion Diseases." Johns Hopkins ABX Guide, The Johns Hopkins University, 2015. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
Crowell TA. Prion Diseases. Johns Hopkins ABX Guide. The Johns Hopkins University; 2015. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases. Accessed October 16, 2019.
Crowell, T. A. (2015). Prion Diseases. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases
Crowell TA. Prion Diseases [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2015. [cited 2019 October 16]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
* Article titles in AMA citation format should be in sentence-case
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