Johns Hopkins ABX Guide
Prion Diseases
Prion Diseases is a topic covered in the Johns Hopkins ABX Guide.
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PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
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PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
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Last updated: January 12, 2020
Citation
Crowell, Trevor A. "Prion Diseases." Johns Hopkins ABX Guide, The Johns Hopkins University, 2020. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
Crowell TA. Prion Diseases. Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases. Accessed January 25, 2021.
Crowell, T. A. (2020). Prion Diseases. In Johns Hopkins ABX Guide. The Johns Hopkins University. Retrieved January 25, 2021, from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases
Crowell TA. Prion Diseases [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2020. [cited 2021 January 25]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540451/all/Prion_Diseases.
* Article titles in AMA citation format should be in sentence-case
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