Prion Diseases
To view the entire topic, please log in or purchase a subscription.
Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:
-- The first section of this topic is shown below --
PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
-- To view the remaining sections of this topic, please log in or purchase a subscription --
PATHOGENS
- Prions are abnormally folded versions of cell membrane proteins that are otherwise normally found throughout the human body.
- Abnormal versions are resistant to most types of proteolytic degradation including resistance to many chemicals and physical methods of inactivation.
- It can induce the conversion of nearby proteins from the normal PrPC form to the abnormal and infective PrPSc form.
- Prions cause transmissible spongiform encephalopathies (TSEs).
- Epidemiology: Annual incidence is about 1.2 cases per million people in the U.S.; increases with age.
There's more to see -- the rest of this entry is available only to subscribers.