Posaconazole

Posaconazole is a topic covered in the Johns Hopkins ABX Guide.

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INDICATIONS

FDA

  • Prophylaxis of invasive aspergillus and disseminated candidiasis in severely immunocompromised hosts, such as hemapoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations
  • Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only

NON-FDA APPROVED USES

  • Treatment of invasive fungal infections (Aspergillosis, Histoplasmosis, Coccidioidomycosis, Candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
  • Maintenance therapy for zygomycosis in patients whose infection has been controlled with standard therapy (e.g. liposomal amphotericin B +/- surgery)
  • Alternative treatment of infections due to hyaline fungi (e.g. Fusarium spp., Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.)
  • Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
  • Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi

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INDICATIONS

FDA

  • Prophylaxis of invasive aspergillus and disseminated candidiasis in severely immunocompromised hosts, such as hemapoietic stem cell transplant recipients with graft vs. host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy- all formulations
  • Treatment of oropharyngeal candidiasis, including itraconazole and/or fluconazole refractory cases- oral suspension only

NON-FDA APPROVED USES

  • Treatment of invasive fungal infections (Aspergillosis, Histoplasmosis, Coccidioidomycosis, Candidiasis) in patients who are intolerant to, or whose infections are refractory to standard therapy.
  • Maintenance therapy for zygomycosis in patients whose infection has been controlled with standard therapy (e.g. liposomal amphotericin B +/- surgery)
  • Alternative treatment of infections due to hyaline fungi (e.g. Fusarium spp., Scedosporium spp., Acremonium spp., Scopulariopsis spp., Purpureocillium spp.)
  • Posaconazole may be effective in combination with surgery for eumycotic mycetoma (localized fungal infections that may involve cutaneous and subcutaneous tissue, fascia and bone).
  • Based on in-vitro data and limited clinical experience, posaconazole may be effective for infections due to certain dematiaceous fungi

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Last updated: March 8, 2020