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    Norovirus

    Christopher J. Hoffmann, M.D., M.P.H.
    Norovirus is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Small, non-enveloped, single-stranded positive-sense RNA virus.
    • Noroviruses are 1 of 5 genera in the Caliciviridae family.
      • Sapoviruses are another genus in the family that also cause acute gastroenteritis.
    • Noroviruses are grouped into genogroups, numbering six currently known (I, II, and IV cause human infections), further divided into genetic clusters.
      • Genogroup II, genotype 4 (II.4) is most commonly associated with outbreaks and severe disease.
      • Genogroup I generally causes less severe disease and a lower attack rate partly because of an association between ABO blood type and infection.
      • Total 25 genotypes known among GI, GII and GIV.
    • Previously known as "Norwalk-like viruses."

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    Last updated: December 6, 2017

    Citation

    Hoffmann, Christopher J. "Norovirus." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540392/all/Norovirus.
    Hoffmann CJ. Norovirus. Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540392/all/Norovirus. Accessed March 24, 2019.
    Hoffmann, C. J. (2017). Norovirus. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540392/all/Norovirus
    Hoffmann CJ. Norovirus [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 March 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540392/all/Norovirus.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Norovirus ID - 540392 A1 - Hoffmann,Christopher,M.D., M.P.H. Y1 - 2017/12/06/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540392/all/Norovirus PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -