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Plasmodium is a topic covered in the Johns Hopkins ABX Guide.

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  • Malaria is caused by intraerythrocytic Plasmodium protozoa belonging to the Apicomplexa group, transmitted by night-time or pre-dawn biting female Anopheles sp. mosquitoes.
  • CDC confirmed 1,517 U.S. cases in 2015, a decrease of 208 cases from 2014.[14]
    • P. falciparum (67% of U.S. cases)
      • Invades RBCs of all stages
      • Causes the most severe and lethal illness
        • RBCs rosette and sequester in microvasculature and damage heart, brain, kidney, lung, placenta.
    • P. vivax
      • Most common type outside of sub-Saharan Africa, survives at lower temperatures and higher elevations.[14]
      • Preferentially invades reticulocytes and requires Duffy antigen for RBC entry
        • Less prevalent in sub-Saharan Africa, as population lacks the Duffy antigen[14]
      • Persists in hepatocytes as hypnozoites for months to years
      • Eradication requires treatment of both liver (hypnozoite) and blood (schizont) stages.
    • P. ovale
      • Can persist in hepatocytes as hypnozoites for months to years
      • Eradication requires treatment of both liver and blood stages.
    • P. malariae
      • Infects older RBCs and causes low-level parasitemia and chronic, low-grade infection
    • P. knowlesi: a monkey malaria parasite, causes human malaria in Southeast Asia, morphologically resembles P. malariae
      • Both uncomplicated and severe disease occur at low parasitemia. IV artesunate recommended for parasitemia > 15,000/μL.[13]
  • Life cycle: female anopheline mosquito bites human host and injects sporozoites, which invade hepatocytes and mature into schizonts (exo-erythrocytic schizogony), which rupture and release merozoites that invade RBCs. In RBCs, ring stage trophozoites mature into schizonts (erythrocytic schizogony), followed by rupture of RBCs and a new cycle of RBC invasion.

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Last updated: April 5, 2019


Spacek, Lisa A. "Plasmodium." Johns Hopkins ABX Guide, The Johns Hopkins University, 2019. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540330/all/Plasmodium.
Spacek LA. Plasmodium. Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540330/all/Plasmodium. Accessed April 24, 2019.
Spacek, L. A. (2019). Plasmodium. In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540330/all/Plasmodium
Spacek LA. Plasmodium [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2019. [cited 2019 April 24]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540330/all/Plasmodium.
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TY - ELEC T1 - Plasmodium ID - 540330 A1 - Spacek,Lisa,M.D., Ph.D. Y1 - 2019/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540330/all/Plasmodium PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -