Johns Hopkins ABX Guide
Lymphogranuloma venereum (LGV)
MICROBIOLOGY
- LGV due to Chlamydia trachomatis L1, L2 and L3 serovars.
- All chlamydia, including those serovars causing LGV, are obligate intracellular microorganisms but LGV serovars are lymphotropic. May cause systemic disease rather than superficial mucosal infection.
- LGV is distinct from other chlamydia serovars causing either common genital chlamydial disease (serovars D-K) or trachoma (serovars A-C).
- LGV strains infect macrophages and spread to lymph nodes which are different from other C. trachomatis strains that are usually restricted to the epithelial cells of the conjunctiva and urogenital mucosa.
- This tropism likely accounts for the differing clinical features and severity of LGV infection when compared with other strains.
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Last updated: November 14, 2021
Citation
Tuddenham, Susan, and Noreen A Hynes. "Lymphogranuloma Venereum (LGV)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2021. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540328/all/Lymphogranuloma_venereum__LGV_.
Tuddenham S, Hynes NA. Lymphogranuloma venereum (LGV). Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540328/all/Lymphogranuloma_venereum__LGV_. Accessed May 2, 2025.
Tuddenham, S., & Hynes, N. A. (2021). Lymphogranuloma venereum (LGV). In Johns Hopkins ABX Guide. The Johns Hopkins University. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540328/all/Lymphogranuloma_venereum__LGV_
Tuddenham S, Hynes NA. Lymphogranuloma Venereum (LGV) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2021. [cited 2025 May 02]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540328/all/Lymphogranuloma_venereum__LGV_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Lymphogranuloma venereum (LGV)
ID - 540328
A1 - Tuddenham,Susan,M.D.
AU - Hynes,Noreen,M.D., M.P.H., D.T.M.&H.
Y1 - 2021/11/14/
BT - Johns Hopkins ABX Guide
UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540328/all/Lymphogranuloma_venereum__LGV_
PB - The Johns Hopkins University
DB - Pediatrics Central
DP - Unbound Medicine
ER -
