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    Klebsiella granulomatis (Granuloma inguinale, Donovanosis)

    Noreen A. Hynes, M.D., M.P.H., D.T.M.&H.
    Klebsiella granulomatis (Granuloma inguinale, Donovanosis) is a topic covered in the Johns Hopkins ABX Guide.

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    MICROBIOLOGY

    • Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis) is a member of the family Enterobacteriaceae.
      • Reclassification is based upon nucleotide relatedness to other Klebsiella spp. especially to K. rhinoscleromatis, another tropical infection (nasal).
        • Pleomorphic, intracellular (macrophages > neutrophils), Gram-negative bacillus surrounded by a well-defined bipolar staining capsule (seen with Wright, Giemsa or Leishman stain)
        • Organism has safety-pin appearance with stain under microscopy.
    • Organism difficult to demonstrate microbiologically because it does not grow on any standard microbiological laboratory media.
    • Culture achieved in the research settings using peripheral blood mononuclear cells cultivated with fetal calf serum after exposure to vancomycin and metronidazole for decontamination.
      • Culture also has been successful on cyclohexamide-treated Hep-2 cell monolayers in RPMI 1640 medium, supplemented with fetal calf serum, penicillin, and vancomycin.

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    Last updated: April 5, 2017

    Citation

    Hynes, Noreen A. "Klebsiella Granulomatis (Granuloma Inguinale, Donovanosis)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_.
    Hynes NA. Klebsiella granulomatis (Granuloma inguinale, Donovanosis). Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_. Accessed April 21, 2019.
    Hynes, N. A. (2017). Klebsiella granulomatis (Granuloma inguinale, Donovanosis). In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_
    Hynes NA. Klebsiella Granulomatis (Granuloma Inguinale, Donovanosis) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 April 21]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Klebsiella granulomatis (Granuloma inguinale, Donovanosis) ID - 540301 A1 - Hynes,Noreen,M.D., M.P.H., D.T.M.&H. Y1 - 2017/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_ PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -