Johns Hopkins ABX Guide →Pathogens →Bacteria

Klebsiella granulomatis (Granuloma inguinale, Donovanosis)

Noreen A. Hynes, M.D., M.P.H., D.T.M.&H.

Klebsiella granulomatis (Granuloma inguinale, Donovanosis) is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis) is a member of the family Enterobacteriaceae.
- Reclassification is based upon nucleotide relatedness to other Klebsiella spp. especially to K. rhinoscleromatis, another tropical infection (nasal).
  - Pleomorphic, intracellular (macrophages > neutrophils), Gram-negative bacillus surrounded by a well-defined bipolar staining capsule (seen with Wright, Giemsa or Leishman stain)
  - Organism has safety-pin appearance with stain under microscopy.
Organism difficult to demonstrate microbiologically because it does not grow on any standard microbiological laboratory media.
Culture achieved in the research settings using peripheral blood mononuclear cells cultivated with fetal calf serum after exposure to vancomycin and metronidazole for decontamination.
- Culture also has been successful on cyclohexamide-treated Hep-2 cell monolayers in RPMI 1640 medium, supplemented with fetal calf serum, penicillin, and vancomycin.

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Last updated: April 5, 2017

Citation

Hynes, Noreen A. "Klebsiella Granulomatis (Granuloma Inguinale, Donovanosis)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2017. Pediatrics Central, peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_.

Hynes NA. Klebsiella granulomatis (Granuloma inguinale, Donovanosis). Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_. Accessed January 22, 2019.

Hynes, N. A. (2017). Klebsiella granulomatis (Granuloma inguinale, Donovanosis). In Johns Hopkins ABX Guide. Available from https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_

Hynes NA. Klebsiella Granulomatis (Granuloma Inguinale, Donovanosis) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2017. [cited 2019 January 22]. Available from: https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_

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TY - ELEC T1 - Klebsiella granulomatis (Granuloma inguinale, Donovanosis) ID - 540301 A1 - Hynes,Noreen,M.D., M.P.H., D.T.M.&H. Y1 - 2017/04/05/ BT - Johns Hopkins ABX Guide UR - https://peds.unboundmedicine.com/pedscentral/view/Johns_Hopkins_ABX_Guide/540301/all/Klebsiella_granulomatis__Granuloma_inguinale__Donovanosis_ PB - The Johns Hopkins University DB - Pediatrics Central DP - Unbound Medicine ER -