Japanese Encephalitis Virus

Japanese Encephalitis Virus is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • Japanese encephalitis virus (JEV): mosquito-borne flavivirus, similar to St. Louis encephalitis virus, Murray Valley encephalitis, yellow fever, dengue, and West Nile virus.
  • Single-stranded, positive sense RNA virus.
  • JEV is transmitted by Culex mosquitoes or species that lay eggs in flooded rice fields.
    • Wild birds are natural host, and domestic pigs are amplifying host. Bats transmit disease in China.
    • Blood transfusion and organ transplantation are potential modes of transmission.
  • JEV is endemic in Asia, Southeast Asia, and the Pacific islands causing about 70,000 cases of infection and 14,000-20,000 deaths per year worldwide.[10]
    • Map of JE transmission
    • Risk of infection estimated at 1/5000 per month of travel to rural areas of Asia where transmission occurs.
    • In temperate Asia, incidence of cases peaks in summer and fall.
    • In tropics or subtropics, transmission occurs in wet seasons but may occur year-round.

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Last updated: January 29, 2017