Hidradenitis Suppurativa is a topic covered in the Johns Hopkins ABX Guide.

To view the entire topic, please or purchase a subscription.

Pediatrics Central™ is an all-in-one application that puts valuable medical information, via your mobile device or the web, in the hands of clinicians treating infants, children, and adolescents. Explore these free sample topics:

Pediatrics Central

-- The first section of this topic is shown below --

PATHOGENS

  • Inflammatory disease around abnormal and dilated hair follicles with secondary involvement of apocrine glands and surrounding structures, often with superinfection.
  • Genetic predisposition possible; 40% have a family history of hidradenitis supperativa.
  • Immune dysregulation in innate and adaptive immune pathways.
  • Pathogenesis believed to start with occlusion and dilation of the pilosebaceous unit → rupture → extrusion of follicular contents into dermis → chemotactic inflammatory response → influx of neutrophils, lymphocytes, histiocytes → abscess formation (thus it is both an inflammatory disease related to immune dysregulation and infectious disease).
    • Infection appears to be a result of inflammatory occlusion of ducts rather than the underlying process for hidradenitis suppurativa.
  • Microbiology: culture may yield mixed aerobic/anaerobic bacteria with S. epidermidis and S. aureus most commonly isolated.
    • Up to 50% of patients are culture negative.

-- To view the remaining sections of this topic, please or purchase a subscription --

Last updated: September 27, 2019