Hepatitis E

Juhi Moon, M.D.
Hepatitis E is a topic covered in the Johns Hopkins ABX Guide.

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MICROBIOLOGY

  • RNA virus transmitted via enteric routes in epidemics and sporadic cases, similar to HAV.
    • Modes of transmission include waterborne, zoonotic and less commonly through blood transfusion and perinatally.
  • Four genotypes (all belong to one serotype) detected in humans, distinct means of transmission suspected.
    • Genotypes 1, 2: predominantly fecal-contaminated water in developing countries worldwide.
    • Genotypes 3, 4: worldwide zoonotic transmission from unclear sources but some significant association with insufficiently cooked game meat or pork products along with shellfish in North America, Western Europe, and Japan.

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MICROBIOLOGY

  • RNA virus transmitted via enteric routes in epidemics and sporadic cases, similar to HAV.
    • Modes of transmission include waterborne, zoonotic and less commonly through blood transfusion and perinatally.
  • Four genotypes (all belong to one serotype) detected in humans, distinct means of transmission suspected.
    • Genotypes 1, 2: predominantly fecal-contaminated water in developing countries worldwide.
    • Genotypes 3, 4: worldwide zoonotic transmission from unclear sources but some significant association with insufficiently cooked game meat or pork products along with shellfish in North America, Western Europe, and Japan.

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Last updated: September 27, 2019