Hepatitis B (HBV) vaccines

Fidelia Bernice, Pharm.D., BCIDP, Janessa M. Smith, PharmD, BCPS
Pediatric Dosing Author: Bethany Sharpless Chalk, Pharm.D., BCPPS


  • Hepilsav-B: yeast-derived vaccine created with a novel adjuvant Toll-like receptor 9 (TLR9) agonist adjuvant
  • Recombivax HB: recombinant vaccine produced by Saccharomyces cerevisiae (baker’s yeast).
  • Engerix-B: recombinant vaccine, also produced by Saccharomyces cerevisiae.
  • Twinrix: bivalent vaccine providing protection against both hepatitis A and B: HAV (720 ELISA units/mL) and HBV (20mcg HBsAg/mL).
  • Comvax: bivalent vaccine providing protection against both Haemophilus influenzae type b and hepatitis B virus (no longer available in the U.S.)

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Last updated: October 3, 2020